Answer:
Yes, there is a possibility.
Explanation:
Stars move with respect to each other. They typically orbit the center of the galaxy, but their orbits are not synchronous and do not lie on the same plane. So, the distances between stars change all the time. The projected distances change as well and the stars appear to move on the sky: this is their so-called proper motion.
Amid a myriad of drifting stars, the shape of Orion as defined by its brightest stars is slowly rearranged into a new pattern as time goes by, revealing how constellations are ephemeral.
Reference:
https://www.esa.int/Science_Exploration/Space_Science/Gaia/The_future_of_the_Orion_constellation
https://www.quora.com/Do-constellations-change-in-shape-after-many-years