Answer:
Both can be correct, depending on the words. You may expect more than one difference. For example:
What is the difference between a "smuggler" and a "pirate"?
(I assume that these words are very similar, and there is only a small difference.)
What are the differences between a "smuggler" and a "pirate"?
(I assume that these are different enough that there are multiple differences.)
It doesn't necessarily matter how many things are actually different, only how many you expect.
Explanation:
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